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KMID : 0604520170430010011
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Journal of the Society of Cosmetic Scientists of Korea
2017 Volume.43 No. 1 p.11 ~ p.18
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Electrospray-assisted Preparation of Polymer Microparticles Containing Water-insoluble Bioactive Compounds
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Hwang Yoon-Kyun
Jeong Min-Kuk
Cho Sung-Yeon
Park Sung-Il
Cho Eun-Chul
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Abstract
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An anti-aging compound ethyl (4-(2,3-dihydro-1H-indene-5-carboxyamido) benzoate) rapidly crystallizes in emulsion systems, and a flavonoid 3,5,7-trihydroxy-4'-methoxy-8-prenylflavone bearing a whitening function causes coloration of cosmetic compounds when mixed with metal oxides. In this study, an electrospray method was used to encapsulate water-insoluble bioactive compounds in polymeric microparticles. Poly (methyl methacrylate) and polycaprolactone were used to encapsulate ethyl (4-(2,3-dihydro-1H-indene-5-carboxyamido) benzoate) and 3,5,7-trihydroxy-4'-methoxy-8-prenylflavone, respectively. It was found that polymer concentration, the structure of electrospray nozzle, and compatibility between polymers and bioactive compounds were important factors in the preparation of the particles. Polycaprolactone particles encapsulating 3,5,7-trihydroxy-4'-methoxy-8-prenylflavone was effective in preventing coloration of a cosmetic compound when mixed with metal oxides.
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KEYWORD
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electrospray , polymer microparticles , water-insoluble bioactive compounds , prevention of coloration
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